Product Name :
Biotin Conjugated Mouse IL-6 Recombinant Rabbit Monoclonal Antibody [PSH0-60]
Predicted band size :
Observed band size :
Synonyms:
Interleukin BSF 2 antibody B cell differentiation factor antibody B cell stimulatory factor 2 antibody B-cell stimulatory factor 2 antibody BSF 2 antibody BSF-2 antibody BSF2 antibody CDF antibody CTL differentiation factor antibody Cytotoxic T cell differentiation factor antibody 展开
Function :
Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. In addition, osteoblasts secrete IL-6 to stimulate osteoclast formation. Smooth muscle cells in the tunica media of many blood vessels also produce IL-6 as a pro-inflammatory cytokine. IL-6’s role as an anti-inflammatory myokine is mediated through its inhibitory effects on TNF-alpha and IL-1 and its activation of IL-1ra and IL-10. There is some early evidence that IL-6 can be used as an inflammatory marker for severe COVID-19 infection with poor prognosis, in the context of the wider coronavirus pandemic. IL-6 is secreted by macrophages in response to specific microbial molecules, referred to as pathogen-associated molecular patterns (PAMPs).Sulforaphane site These PAMPs bind to an important group of detection molecules of the innate immune system, called pattern recognition receptors (PRRs), including Toll-like receptors (TLRs). These are present on the cell surface and intracellular compartments and induce intracellular signaling cascades that give rise to inflammatory cytokine production. IL-6 is an important mediator of fever and of the acute phase response. IL-6 stimulates the inflammatory and auto-immune processes in many diseases such as multiple sclerosis, neuromyelitis optica spectrum disorder (NMOSD), diabetes, atherosclerosis, depression, Alzheimer’s disease, systemic lupus erythematosus, multiple myeloma, prostate cancer, Behçet’s disease, rheumatoid arthritis, and intracerebral hemorrhage.
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Recombinant full length of mouse IL6 protein.
Species reactivity:
Mouse
Verify application:
ELISA(Det)
Coupling :
Biotin
Clone number:
PSH0-60
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃.6-Bromo-7-fluoroisobenzofuran-1(3H)-one Purity Avoid repeated freeze / thaw cycles.PMID:33618591
Storage buffer solution:
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% ProClin367.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 24 kDa
Positive control :
Recombinant mouse IL6 protein.