(Grant Numbers 81061120525 and CCI-109605). Author particulars Department of Pharmacology, Wellness Science Center, Peking University, 38 Xue Yuan Road, Beijing 100191, China. 2Beijing N N Genetech Business, Beijing, China. 3Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada. 4Department of Pharmacology, Ningxia Health-related University, Yinchuan 750004, China. five Department of the Integration of Chinese and Western Medicine, Overall health Science Center, Peking University, Beijing 100191, China.Received: 5 December 2013 Accepted: 17 January 2014 Published: 22 JanuaryReferences 1. Voulgari C, Papadogiannis D, Tentolouris N: Diabetic cardiomyopathy: from the pathophysiology with the cardiac myocytes to present diagnosis and management methods. Vasc Well being Threat Manag 2010, six:883?03. 2. Boudina S, Abel ED: Diabetic cardiomyopathy, causes and effects. Rev Endocr Metab Disord 2010, 11:31?9. three. Murarka S, Movahed MR: Diabetic cardiomyopathy. J Card Fail 2010, 16:971?79. 4. Nunes S, Soares E, Pereira FC, Reis F: The role of inflammation in diabetic cardiomyopathy. Int J Infereron Cytokine Mediator Res 2012, four:59?three. 5. Fredersdorf S, Thumann C, Zimmermann WH, Vetter R, Graf T, Luchner A, Riegger GA, Schunkert H, Eschenhagen T, Weil J: Improved myocardial SERCA expression in early kind 2 diabetes mellitus is insulin dependent: In vivo and in vitro data. Cardiovasc Diabetol 2012, 11:57. six. Hou L, Lian K, Yao M, Shi Y, Lu X, Fang L, He T, Jiang L: Reduction of n3PUFAs, especially DHA and EPA, and enhancement of peroxisomal beta oxidation in form 2 diabetic rat heart. Cardiovasc Diabetol 2012, 11:126. 7. Aragno M, Mastrocola R, Gh?C, Arnoletti E, Bassino E, Alloatti G, Muccioli G: Obestatin induced recovery of myocardial dysfunction in type 1 diabetic rats: underlying mechanisms. Cardiovasc Diabetol 2012, 11:129. eight. Nunes S, Soares E, Fernandes J, Viana S, Carvalho E, Pereira FC, Reis F: Early cardiac changes within a rat model of prediabetes: brain natriuretic peptide over expression seems to be the ideal marker. Cardiovasc Diabetol 2013, 12:44. 9. Bugger H, Abel ED: Rodent models of diabetic cardiomyopathy. Dis Model Mech 2009, 2:454?66. 10. Toye AA, Moir L, Hugill A, Bentley L, Quarterman J, Mijat V, Hough T, Goldsworthy M, Haynes A, Hunter AJ, Browne M, Spurr N, Cox RD: A new mouse model of form 2 diabetes, developed by N-ethyl-nitrosourea mutagenesis, could be the outcome of a missense mutation in the glucokinase gene.2,6-Di(1-pyrazolyl)pyridine Order Diabetes 2004, 53:1577?583. 11. Fajans SS, Bell GI, Polonsky KS: Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young.1234616-13-7 Price N Engl J Med 2001, 345:971?80.PMID:23724934 12. Froguel P, Velho G: Molecular genetics of maturity-onset diabetes in the young. Trends Endocrinol Metab 1999, ten:142?46. 13. Inoue M, Sakuraba Y, Motegi H, Kubota N, Toki H, Matsui J, Toyoda Y, Miwa I, Terauchi Y, Kadowaki T, Shigeyama Y, Kasuga M, Adachi T, Fujimoto N, Matsumoto R, Tsuchihashi K, Kagami T, Inoue A, Kaneda H, Ishijima J, Masuya H, Suzuki T, Wakana S, Gondo Y, Minowa O, Shiroishi T, Noda T: A series of maturity onset diabetes in the young, form two (MODY2) mouse models generated by a large-scale ENU mutagenesis program. Hum Mol Genet 2004, 13:1147?157. 14. van B ck L, Blutke A, Kautz S, Rathkolb B, Klaften M, Wagner S, Kemter E, de Hrab?Angelis M, Wolf E, Aigner B, Wanke R, Herbach N: Phenotypic and pathomorphological traits of a novel mutant mouse model for maturity-onset diabetes of your yo.