Re 1 cm with the microscopic scale corresponded to 0.39 mm of actual thickness. The total score of all five parameters represented the severity of OA progression in every histological section. The sum of all scores from all histological sections of each animal represented the total score for that animal. The statistical evaluation was determined by the median along with the imply on the sums of the total scores of all the animals in every remedy group.Statistical analysisSpecimen collectionAfter the rabbits have been euthanized, treated knee joint specimens were collected by osteotomy three cm above andThe data are expressed as the mean ?the normal deviation on the different measurements. The statistical significance of intergroup variations was analyzed employing one-way evaluation of variance (ANOVA) and the Duncan post-hoc test. Differences with a P value less than 0.05 were considered statistically considerable.Lu et al. BMC Veterinary Study 2013, 9:68 http://biomedcentral/1746-6148/9/Page 11 ofCompeting interests All authors declare that they have no competing interests. Authors’ contributions HTL and made the analysis and wrote the paper. MTS, YFL and JL performed the study and analyzed the information. MSH and YPC analyzed the data. CWC analyzed the data and wrote paper. CHC created research and wrote paper. All authors study and approved the final manuscript. Acknowledgements This study was supported by a grant in the National Science Council, Taiwan (NSC98-2314-B038-005). Author particulars 1 Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, No. 250 Wu-Hsing Street, Xinyi District, Taipei City 110, Taiwan. 2 School of Pharmacy, College of Pharmacy, Taipei Healthcare University, No. 250 Wu-Hsing Street, Xinyi District, Taipei City 110, Taiwan. 3Department of Healthcare Technologies, School of Health-related Laboratory Science Biotechnology, Taipei Medical University, No. 250 Wu-Hsing Street, Xinyi District, Taipei City 110, Taiwan. 4Department of Microbiology and Immunology, College of Medicine, Taipei Medical University, No. 250 Wu-Hsing Street, Xinyi District, Taipei City 110, Taiwan. 5Department of Orthopedics and Traumatology, Taipei Healthcare University Hospital, No. 250 Wu-Hsing Street, Xinyi District, Taipei City 110, Taiwan.630108-94-0 web Received: 17 January 2013 Accepted: 26 March 2013 Published: ten April 2013 References 1. Lohmander LS, Brandt KD, Mazzuca SA, Katz BP, Larsson S, Struglics A, Lane KA: Use of the plasma stromelysin (matrix metalloproteinase three) concentration to predict joint space narrowing in knee osteoarthritis. Arthritis rheumatism 2005, 52(10):3160?167. 2. Thomas CM, Fuller CJ, Whittles CE, Sharif M: Chondrocyte death by apoptosis is related with cartilage matrix degradation.Formula of 4-Chloro-6-methyl-7-azaindole Osteoarthritis cartil OARS Osteoarthritis Res Soc 2007, 15(1):27?four.PMID:23558135 3. Attur MG, Patel RN, Patel PD, Abramson SB, Amin AR: Tetracycline upregulates COX-2 expression and prostaglandin E2 production independent of its effect on nitric oxide. J Immunol 1999, 162(six):3160?167. four. Verbruggen G: Chondroprotective drugs in degenerative joint diseases. Rheumatology 2006, 45(2):129?38. five. Pelletier JP, Martel-Pelletier J, Raynauld JP: Most recent developments in approaches to lower the progression of structural adjustments in osteoarthritis: now and tomorrow. Arthritis res therap 2006, 8(2):206. 6. Pelletier JP: Rationale for the use of structure-modifying drugs and agents inside the treatment of osteoarthritis. Osteoarthritis and cartilage/ OARS. Osteoarthritis R.
